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Updated: May 31, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Biopsy-Proven Acute Tubular Necrosis due to Vancomycin Toxicity
Farheen Shah-Khan1, Marc H Scheetz, Cybele Ghossein
1Division of Nephrology, Northwestern Memorial Hospital, Chicago, IL 60611, USA.
Abstract:
Vancomycin (VAN) has been associated with acute kidney injury (AKI) since it has been put into clinical use in the 1950's. Early reports of AKI were likely linked to the impurities of the VAN preparation. With the advent of the more purified forms of VAN, the incidence of AKI related to VAN were limited to acute interstitial nephritis (AIN) or as a potentiating agent to other nephrotoxins such as Aminoglycosides. VAN as the sole etiologic factor for nephrotoxic acute tubular necrosis (ATN) has not been described. Here, we report a case of biopsy-proven ATN resulting from VAN.
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