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Updated: May 31, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Allogeneic Stem Cell Transplantation for Metastatic Renal Cell Cancer (RCC)
Marco Bregni1, Fabio Ciceri, Jacopo Peccatori
1Department of Hematology, Istituto Scientifico San Raffaele, Milano, Italy.
Abstract:
A variety of therapeutic options are now available for advanced renal cell cancer, including antiangiogenic and anti-mTOR agents. Allogeneic hematopoietic stem cell transplantation, through its graft-versus-tumor effect, can induce clinical responses and prolonged survival in selected cytokine-refractory patients. However, the still relevant transplant-related mortality due to toxicity and graft-versus-host disease is an obstacle to its widespread use.
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