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Updated: May 31, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Cutaneous drug hypersensitivity: immunological and genetic perspective
Kisalay Ghosh1, Gautam Banerjee, Asok Kumar Ghosal
1Department of Dermatology, MGM Medical College and LSK Hospital, Kishanganj, Bihar, India.
Abstract:
Drug hypersensitivity is an unpredictable, immunologically mediated adverse reaction, clustered in a genetically predisposed individual. The role of "hapten concept" in immune sensitization has recently been contested by the "pharmacological interaction" hypothesis. After completion of the "human genome project" and with the availability of high-resolution genotyping, genetic susceptibility to hypersensitivity for certain drugs has been proved beyond doubt though the trend is ethnicity and phenotype dependent. Application of this newly acquired knowledge may reduce or abolish the morbidity and mortality associated with cutaneous drug hypersensitivity.
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