Related Experiment Video
Updated: May 31, 2026

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
Published on: March 8, 2024
[Restless legs syndrome and nocturnal leg pain : Differential diagnosis and treatment]
M Hornyak1, K Stiasny-Kolster, S Evers
1Interdisziplinäres Schmerzzentrum, Universitätsklinikum Freiburg, Breisacher Str. 64, 79106, Freiburg, Deutschland. magdolna.hornyak@uniklinik-freiburg.de
Abstract:
Pain in the legs belongs to the five most frequent regional pain symptoms. Restless legs syndrome (RLS) presents a particular differential diagnosis for pain in the legs, which is characterized by a nocturnal urge to move the legs often associated with painful sensations in the legs. It is one of the most common neurological disorders and probably the leading cause of nocturnal pain in the legs. In this overview, the diagnosis and therapy of RLS as well as aspects of pain therapy of the disorder are presented. In addition, the differential diagnoses for exclusion of other specific causes of nocturnal pain in the legs are discussed.
Related Concept Videos
Restless Leg Syndrome and Night Terrors
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Peripheral Artery Disease IV: Nursing Management
Venous Thrombosis IV: Nursing Management
Varicose Veins I: Introduction
