Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct regions...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Five-year clinical outcomes in patients with significant coronary artery spasm: A propensity score-matched analysis.

International journal of cardiology·2015
Same author

Impact of low dose atorvastatin on development of new-onset diabetes mellitus in Asian population: Three-year clinical outcomes.

International journal of cardiology·2015
Same author

Comparison of diabetic and non-diabetic patients undergoing endovascular revascularization for peripheral arterial disease.

The Journal of invasive cardiology·2015
Same author

An unexpected cause of occult bleeding.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology·2012
Same author

An unsual finding of brain magnetic resonance imaging in a hypertensive patient.

Neurology international·2011
Same author

Cardiac metastasis: a rare involvement of primitive neuroectodermal tumour of the lung.

Pathology oncology research : POR·2011

Related Experiment Video

Updated: May 31, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Primary pigmented nodular adrenocortical disease.

Harris Abdullah Ngow1, Wan Mohd Nowalid Wan Khairina

  • 1International Islamic University of Malaysia/Hospital Tengku Ampuan Afzan, Kulliyyah Of Medicine, Jalan Hospital, Pahang, Malaysia. harrisngow@gmail.com

Endokrynologia Polska
|July 1, 2011
PubMed
Summary
This summary is machine-generated.

Primary pigmented nodular adrenocortical disease (PPNAD) is a rare adrenal tumor causing Cushing's syndrome. Histology reveals characteristic pigmented micronodules, often associated with Carney Complex.

More Related Videos

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

Related Experiment Videos

Last Updated: May 31, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Primary pigmented nodular adrenocortical disease (PPNAD) is a rare adrenal neoplasm.
  • It is a leading cause of corticotrophin-independent Cushing's syndrome, primarily affecting pediatric and young adult populations.
  • PPNAD can occur in isolation or as a component of Carney Complex.

Observation:

  • A case of Carney Complex was referred for adrenalectomy.
  • The surgical procedure was uneventful, with the patient discharged in good condition.
  • Adrenal gland pathology revealed numerous small, black pigmented micronodules (<2mm).

Findings:

  • The histological findings were pathognomonic for primary pigmented nodular adrenocortical disease (PPNAD).
  • The presence of pigmented micronodules is a key diagnostic feature.
  • This case highlights the association between Carney Complex and PPNAD.

Implications:

  • Accurate diagnosis of PPNAD is crucial for managing Cushing's syndrome.
  • Surgical intervention, such as adrenalectomy, can be effective for PPNAD.
  • Understanding the link between PPNAD and Carney Complex aids in comprehensive patient care.