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Abnormal liver function test in Graves' disease: a prospective study of comparison between the hyperthyroid state and
Veerasak Sarinnapakorn1, Pornchanok Noppavetchwich, Thongkum Sunthorntepwarakul
1Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand. veerasak_sarin@yahoo.co.th
Summary
Abnormal liver function tests are common in Graves' disease. While gamma-glutamyl transpeptidase (GGT) normalizes with treatment, serum alkaline phosphatase may increase as patients reach the euthyroid state.
Area of Science:
- Endocrinology
- Hepatology
- Internal Medicine
Background:
- Abnormal liver function tests (LFTs) can occur in hyperthyroidism.
- No prior studies have directly compared LFTs in hyperthyroid versus euthyroid states.
Purpose of the Study:
- Determine the prevalence of abnormal LFTs in Graves' disease.
- Compare LFTs in the hyperthyroid state versus the euthyroid state.
Main Methods:
- Prospective study of 112 new or recurrent Graves' disease patients.
- Compared LFTs at diagnosis and after achieving euthyroid state with antithyroid drugs in 86 patients.
Main Results:
- Elevated serum globulin (30.4%), alkaline phosphatase (25.0%), and gamma-glutamyl transpeptidase (GGT) (23.3%) were most common.
- GGT levels normalized with treatment.
- Serum alkaline phosphatase levels increased by the euthyroid state.
Conclusions:
- Abnormal LFTs are frequent in Graves' disease.
- Treatment improves GGT levels but can lead to increased serum alkaline phosphatase as euthyroid state is reached.
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