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Updated: May 31, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Evolving therapeutic paradigms for advanced prostate cancer
Joshua M Ruch1, Maha H Hussain
1Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan 48109-5946, USA.
Oncology (Williston Park, N.Y.)
|July 2, 2011
Summary
Novel therapeutics are improving survival for metastatic castration-resistant prostate cancer (CRPC). Further advances require personalized medicine based on disease biology and predictive biomarkers.
Area of Science:
- Oncology
- Translational Medicine
Background:
- Metastatic castration-resistant prostate cancer (CRPC) management has advanced with new therapeutics.
- Several agents, including docetaxel, cabazitaxel, sipuleucel-T, and abiraterone, have shown improved survival in clinical trials.
Purpose of the Study:
- To review the progress in improving survival for metastatic CRPC.
- To highlight the need for personalized therapy and further research.
Main Methods:
- Review of recent clinical trial data and therapeutic approvals for metastatic CRPC.
- Analysis of the impact of novel agents on overall survival.
Main Results:
- Significant progress has been made in extending survival for metastatic CRPC patients.
- New agents have demonstrated modest but meaningful improvements in overall survival.
Conclusions:
- While survival has improved, personalized therapy in advanced prostate cancer lags behind other solid tumors.
- Future clinical trials must prioritize high-quality translational science focusing on disease biology, pathways, and predictive biomarkers for personalized treatment strategies.
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