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Related Experiment Video

Updated: May 31, 2026

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

Do microfractures improve high tibial osteotomy outcome?

Walter Pascale1, Simone Luraghi, Laura Perico

  • 1IRCCS Galeazzi Orthopaedic Institute, Milan, Italy. pascalew@tiscali.it

Orthopedics
|July 2, 2011
PubMed
Summary

High tibial osteotomy with microfractures improved patient satisfaction for medial compartment osteoarthritis in genu varum. While both treatments improved knee function, microfractures enhanced long-term patient contentment.

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Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

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Area of Science:

  • Orthopedic Surgery
  • Sports Medicine
  • Biomedical Engineering

Background:

  • Medial compartment osteoarthritis in genu varum often requires surgical intervention.
  • High tibial osteotomy (HTO) is a common procedure to correct knee alignment.
  • The role of adjunctive procedures like microfractures in HTO outcomes is under investigation.

Purpose of the Study:

  • To evaluate the efficacy of microfractures combined with high tibial osteotomy (HTO) for medial compartment osteoarthritis in genu varum.
  • To compare clinical outcomes and patient satisfaction between HTO alone and HTO with microfractures.

Main Methods:

  • A randomized controlled trial involving 40 patients with medial compartment osteoarthritis and genu varum.
  • Patients were assigned to either HTO with microfractures (Group A) or HTO alone (Group B).

Related Experiment Videos

Last Updated: May 31, 2026

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

  • Clinical outcomes were assessed at 5 years using the International Knee Documentation Committee (IKDC) and Lysholm scores, along with patient satisfaction.

    • Main Results:

    • Both groups showed statistically significant improvements in Lysholm and IKDC scores postoperatively, with no significant difference between groups.
    • Patient satisfaction scores were significantly higher in the HTO plus microfractures group compared to the HTO alone group at 5-year follow-up.
    • No significant preoperative differences in satisfaction were noted between the groups.

    Conclusions:

    • High tibial osteotomy is an effective treatment for varus knee with medial degenerative arthritis, particularly for active individuals.
    • Combining microfractures with high tibial osteotomy may lead to enhanced patient satisfaction in the long term.
    • Microfractures may offer additional benefits for patient-reported outcomes following HTO for medial compartment osteoarthritis.