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Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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mTOR Signaling and Cancer Progression

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Targeted Cancer Therapies

Targeted Cancer Therapies

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Related Experiment Video

Updated: May 31, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Cancer stem cells in osteosarcoma: recent progress and perspective.

Bin Liu¹, Wei Ma, R K Jha

¹Department of Orthopedic Surgery, First Affiliated Hospital of Xi'an Jiaotong University, China.

Acta Oncologica (Stockholm, Sweden)

|July 2, 2011

Summary

Osteosarcoma stem cells (OSCs) drive tumor growth, metastasis, and drug resistance. Targeting these cancer stem cells (CSCs) offers a promising strategy for eradicating osteosarcoma and preventing recurrence.

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Area of Science:

Oncology
Stem Cell Biology
Cancer Research

Background:

The cancer stem cell (CSC) hypothesis posits that a small subpopulation of cells drives tumor initiation, progression, and recurrence.
Osteosarcoma stem cells (OSCs) are implicated in tumor development, metastasis, and resistance to therapy.
Recent advances in stem cell biology provide growing evidence for the CSC hypothesis in various cancers, including osteosarcoma.

Purpose of the Study:

To review current progress in understanding osteosarcoma stem cells.
To explore their isolation, identification, and surface markers.
To examine the link between drug resistance, metastasis, and associated signaling pathways.

Main Methods:

Literature review of studies on osteosarcoma stem cells.

Main Results:

Osteosarcoma stem cells have been successfully isolated and identified using diverse methods.
CSCs are crucial for osteosarcoma initiation, proliferation, metastasis, and therapeutic resistance.
Targeting CSCs by understanding their microenvironment interactions is a potential therapeutic strategy.

Conclusions:

Research on osteosarcoma stem cells is in its early stages, with significant challenges remaining.
Further investigation is needed to develop targeted therapies, elucidate drug resistance mechanisms, and understand the role of CSCs in metastasis.
Identifying and correcting pathway imbalances in osteosarcoma stem cells is critical for effective treatment.