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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

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Related Experiment Video

Updated: May 31, 2026

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
11:42

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

Big science for small cells: systems approaches for platelets.

Stephen P Holly1, Leslie V Parise

  • 1Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7260, USA.

Current Drug Targets
|July 2, 2011
PubMed
Summary
This summary is machine-generated.

Platelets drive dangerous blood clots in diseases like atherosclerosis and cancer. Systems biology offers new ways to find safer antiplatelet targets, reducing bleeding risks associated with current therapies.

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Related Experiment Videos

Last Updated: May 31, 2026

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
11:42

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

Area of Science:

  • Hematology and Thrombosis
  • Systems Biology
  • Drug Discovery

Background:

  • Platelets are crucial in forming life-threatening thrombi during pathological conditions including atherosclerosis, diabetes, metastatic cancer, sickle cell disease, and obesity.
  • Thrombi contribute to major causes of death, such as myocardial infarction (MI) and stroke.
  • Current antiplatelet drugs, while effective, carry significant risks of bleeding complications.

Purpose of the Study:

  • To explore novel antiplatelet strategies using systems biology approaches.
  • To identify new therapeutic targets for safer antiplatelet interventions.
  • To provide an overview of systems biology applications in platelet research.

Main Methods:

  • Genomics
  • Aptamer discovery
  • Systems biology approaches

Main Results:

  • Systems biology provides opportunities to identify novel platelet targets.
  • These approaches can lead to the development of potentially safer antiplatelet strategies.
  • Exploiting novel targets is emphasized for therapeutic benefit.

Conclusions:

  • Systems biology offers promising avenues for developing safer antiplatelet therapies.
  • Identifying and targeting novel platelet pathways can mitigate bleeding risks.
  • Further research into systems biology approaches is crucial for advancing antiplatelet treatments.