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Updated: May 31, 2026
08:32
Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
Adiponectin receptor signalling in the brain.
John Thundyil1, Dale Pavlovski, Christopher G Sobey
1School of Biomedical Sciences, University of Queensland, Brisbane, Qld, Australia.
British Journal of Pharmacology
|July 2, 2011
Summary
Adiponectin, a hormone regulating metabolism, and its brain receptors play roles in neurological functions. Further research is needed to clarify their involvement in brain disorders and potential therapeutic applications.
Area of Science:
- Endocrinology
- Neuroscience
- Metabolic Regulation
Background:
- Adiponectin is an adipocyte-derived hormone crucial for lipid and glucose metabolism.
- Adiponectin receptors (AdipoR1, AdipoR2, T-cadherin) mediate actions via signaling pathways like AMP-activated protein kinase and p38-MAPK.
- Evidence indicates widespread expression of adiponectin receptors in various brain regions, including the hypothalamus and cortical neurons.
Purpose of the Study:
- To review the functions, structure, and actions of adiponectin.
- To summarize the evidence for adiponectin receptor expression in the brain.
- To explore the involvement of adiponectin signaling in brain disorders and its therapeutic potential.
Main Methods:
- Literature review of studies on adiponectin and its receptors.
- Analysis of research on adiponectin receptor expression in brain tissues.
- Examination of studies investigating the role of adiponectin in neurological conditions.
Main Results:
- Adiponectin regulates metabolism and has diverse biological functions.
- Adiponectin receptors are present in key brain areas, suggesting central roles.
- The precise functions of adiponectin in brain diseases are not yet fully understood.
Conclusions:
- Adiponectin and its brain receptors represent a potential therapeutic target for neurological disorders.
- Further investigation into adiponectin's role in the brain is warranted.
- Modulating adiponectin receptor signaling may offer novel treatment strategies for brain diseases.
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