Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffuse gallium-67 uptake in radiation pneumonitis.

M Kataoka1, M Kawamura, N Ueda

  • 1Department of Radiology, Ehime University School of Medicine, Onsen-gun, Japan.

Clinical Nuclear Medicine
|October 1, 1990
PubMed
Summary

Gallium-67 (Ga-67) imaging can detect radiation pneumonitis extending beyond the irradiated lung. This nuclear medicine technique offers superior assessment of radiation pneumonitis extent compared to chest X-rays.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Double-blind, Placebo-controlled, Multicenter, Prospective, Randomized Study of Beraprost Sodium Treatment for Cats with Chronic Kidney Disease.

Journal of veterinary internal medicine·2017
Same author

Role of anti-oncomirs miR-143 and -145 in human colorectal tumors.

Cancer gene therapy·2010
Same author

Expression pattern of novel chick T-box gene, Tbx20.

Development genes and evolution·2002
Same author

Role of FK506-binding protein 12 in development of the chick embryonic heart.

Biochemical and biophysical research communications·2001
Same author

Influence of calcium on proliferation and phenotype alteration of cardiomyocyte in vitro.

Journal of cellular physiology·1998
Same author

Function of FK506 binding protein (FKBP) in chick embryonic cardiac development.

Heart and vessels·1997

Area of Science:

  • Nuclear Medicine
  • Pulmonary Medicine
  • Oncology

Background:

  • Radiation pneumonitis is a common complication following thoracic radiotherapy for non-small-cell lung cancer.
  • Assessing the spatial extent of radiation pneumonitis is crucial for patient management and understanding treatment effects.

Purpose of the Study:

  • To evaluate the clinical utility of Gallium-67 (Ga-67) imaging in assessing the extent of radiation pneumonitis.
  • To compare the diagnostic performance of Ga-67 imaging with conventional chest radiography.

Main Methods:

  • Retrospective review of 12 patients treated with radiotherapy for non-small-cell lung cancer who developed radiation pneumonitis.
  • Analysis of Ga-67 scintigraphy findings, including uptake patterns (diffuse vs. localized).
  • Correlation of imaging findings with chest radiography and histopathology where available.

Related Experiment Videos

Main Results:

  • Diffuse bilateral Ga-67 uptake was observed in 5 of 12 patients.
  • In 7 patients, Ga-67 uptake was confined to the irradiated lung area.
  • Chest radiography showed infiltrates solely within the irradiated lung fields.
  • Histopathology confirmed interstitial pneumonitis outside the radiation field in cases with diffuse Ga-67 uptake.

Conclusions:

  • Radiation pneumonitis can manifest and extend beyond the directly irradiated lung tissue.
  • Ga-67 imaging demonstrates greater sensitivity than chest radiography in delineating the full spatial extent of radiation pneumonitis.
  • Ga-67 scintigraphy is a valuable tool for comprehensive assessment of radiation-induced lung injury.