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Panax ginseng C.A Meyer root extract for moderate chronic obstructive pulmonary disease (COPD): study protocol for a
Charlie C Xue1, Johannah L Shergis, Anthony L Zhang
1Discipline of Chinese Medicine, School of Health Sciences and Health Innovations Research Institute (HIRi), RMIT University, Bundoora, VIC, Australia. charlie.xue@rmit.edu.au
Trials
|July 2, 2011
Summary
This study investigates Panax ginseng for chronic obstructive pulmonary disease (COPD) symptom relief and quality of life (QoL) improvements. Rigorous clinical trials are needed to confirm ginseng
Area of Science:
- Respiratory Medicine
- Pharmacology
- Clinical Trial Design
Background:
- Chronic obstructive pulmonary disease (COPD) significantly reduces quality of life (QoL) and increases mortality risk.
- Traditional Chinese medicine utilizes ginseng for respiratory ailments, with preliminary studies suggesting therapeutic potential in COPD.
- Existing clinical trials on ginseng for COPD are often small and may have biases, necessitating robust research.
Purpose of the Study:
- To assess the therapeutic efficacy and safety of a standardized Panax ginseng root extract in individuals with moderate COPD (Stage II).
- To evaluate the impact of ginseng on symptomatic relief and quality of life (QoL) improvements.
- To focus on patients with moderate COPD, defined by specific lung function parameters (FEV1/FVC < 0.7 and FEV₁ 50%-80% predicted).
Main Methods:
- A randomized, multi-center, double-blind, placebo-controlled trial involving 168 participants.
- Participants received either 100 mg ginseng capsules or a matching placebo twice daily for 24 weeks.
- Primary outcomes measured using validated QoL questionnaires (SGRQ, SF-36, CAT); secondary outcomes include lung function, medication use, and exacerbations. Safety assessed via blood tests and adverse events.
Conclusions:
- Results from this rigorously designed study may inform the development of novel therapeutic strategies for chronic respiratory diseases, particularly COPD.
- The study protocol can serve as a model for future high-quality clinical trials investigating herbal medicinal products.
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