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Candidiasis

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...

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Skin Diseases and Disorders

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Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...

Sexually Transmitted Infections

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Cryptococcal Meningitis

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Related Experiment Video

Updated: May 31, 2026

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

Published on: December 8, 2011

Candidiasis (vulvovaginal).

¹General Practice, Glasgow University, Glasgow, Scotland.

BMJ Clinical Evidence

|July 2, 2011

Summary

This summary is machine-generated.

This systematic review evaluates treatments for vulvovaginal candidiasis (VVC). It found various drug and alternative therapies effective for VVC in non-pregnant women, with evidence quality varying by intervention.

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Area of Science:

Gynecology
Infectious Diseases
Evidence-Based Medicine

Background:

Vulvovaginal candidiasis (VVC) is a common cause of vaginitis, with Candida albicans responsible for most cases.
Bacterial vaginosis is the only more common cause of vaginitis.

Purpose of the Study:

To systematically review the effectiveness and safety of drug and alternative treatments for VVC in non-pregnant women.
To evaluate treatments for acute, recurrent, and asymptomatic VVC, including partner treatment and complementary therapies.

Main Methods:

Conducted a systematic review of 61 studies, including systematic reviews, randomized controlled trials (RCTs), and observational studies.
Searched major databases (Medline, Embase, Cochrane Library) up to March 2009 and included harms alerts from regulatory agencies.
Utilized GRADE methodology to evaluate the quality of evidence for various interventions.

Main Results:

Identified numerous interventions for VVC, including oral and intravaginal drug treatments, complementary therapies, and partner treatment.
Evidence quality for effectiveness and safety varied across the evaluated interventions.
Included information on douching, garlic, boric acid, nystatin, imidazoles, tea tree oil, fluconazole, itraconazole, and Lactobacillus acidophilus.

Conclusions:

Presents a comprehensive overview of the effectiveness and safety of diverse VVC interventions for non-pregnant women.
Highlights the range of available treatments, from conventional drugs to complementary and alternative medicine (CAM) options.
Provides evidence-based information to guide clinical decision-making for VVC management.