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The biochemistry of asthma
1Universit of Virginia School of Medicine, Pediatric Respiratory Medicine, Charlottes, VA 22908-0386, USA. bmg3g@virginia.edu
Biochimica Et Biophysica Acta
|July 2, 2011
Summary
Asthma exhibits diverse biochemical phenotypes. Biomarker analysis reveals airway biochemistry, enabling targeted treatments for distinct asthma patient subgroups.
Area of Science:
- Biochemistry
- Pulmonology
- Medical Biomarkers
Background:
- Asthma is a heterogeneous disease with distinct biochemical phenotypes among patients.
- Biochemical abnormalities in the asthmatic airway are increasingly recognized.
Purpose of the Study:
- To review the biochemical determinants of asthma heterogeneity.
- To highlight the role of biomarkers in understanding asthma biochemistry.
Main Methods:
- Biomarker analysis of the asthmatic airway.
- Review of biochemical abnormalities including enzyme activities, pH, and metabolite levels.
Main Results:
- Identified numerous biochemical determinants of asthma heterogeneity.
- Exhaled nitric oxide as a biomarker reflecting complex airway biochemistry.
Conclusions:
- Airway biochemistry is informative and therapeutically relevant.
- Understanding asthma biochemistry will facilitate new diagnostic tests and targeted treatments for specific patient subpopulations.
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