Cystic fibrosis. IV. Structural analysis of a chloroform soluble compound isolated from gastric juice

Cystic fibrosis (CF) is the most common autosomal disorder yet its cause is unknown. During an investigation of chloroform soluble fraction compounds of samples of gastric secretions from children with CF, a new substance was isolated. The new compound is concerned in alteration of membrane phospholipid composition, and changes in the activity of the enzyme transferring long-chain acyl moieties. Its structure is investigated, evaluated and discussed in relation to CF.