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Related Experiment Video

Updated: May 31, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

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Published on: June 23, 2023

Endothelial dysfunction during acute alcohol withdrawal syndrome.

Thomas Jochum¹, Markus Weissenfels, Andrea Seeck

¹Pain and Autonomics - Integrative Research (PAIR), Department of Psychiatry and Psychotherapy, University Hospital, Jena 07743, Germany.

Drug and Alcohol Dependence

|July 2, 2011

Summary

Peripheral endothelial dysfunction is present in acute alcohol withdrawal syndrome. This dysfunction, indicated by impaired microcirculation, was observed before and after treatment, suggesting no major treatment influence.

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Area of Science:

Cardiovascular Research
Microcirculation Studies
Alcohol Withdrawal Syndrome

Background:

Endothelial dysfunction (EF) is a key factor in cardiovascular diseases.
Investigated EF in acute alcohol withdrawal syndrome (AWS).
Assessed microcirculation using post-occlusive reactive hyperemia (PORH) and spectral analysis of skin vasomotion.

Purpose of the Study:

To analyze microcirculation and endothelial function in patients with AWS.
To evaluate changes in EF before and after 24 hours of treatment.
To explore detailed blood flow dynamics using spectral analysis segmentation.

Main Methods:

Studied 30 unmedicated AWS patients and matched controls.
Measured capillary blood flow via PORH test and spectral analysis.
Quantified withdrawal severity using the alcohol withdrawal scale (AW scale).

Main Results:

AWS patients showed blunted hyperemic response (increased TP, decreased PORH indices).
Spectral analysis of vasomotion was not significantly altered at rest.
Segmentation analysis revealed resting cardiac band alterations and post-treatment differences between groups.

Conclusions:

Peripheral endothelial dysfunction is evident in acute alcohol withdrawal.
Treatment with clomethiazole showed no major influence on observed EF markers.
Further research is needed to link EF to cardiac morbidity in AWS.