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Long-term hypotensive effect of parathyroid hormone in stroke prone spontaneously hypertensive rats
D Neuser1, R Schulte-Brinkmann, A Knorr
1Bayer AG, Department of Pharmacology, Pharma Research Center, Wuppertal 1, F.R.G.
European Journal of Pharmacology
|July 17, 1990
Abstract:
The influence of long-term treatment with parathyroid hormone (PTH) on blood pressure (BP) development in stroke prone spontaneously hypertensive rats (SHR/SP) was investigated. Acute i.v. administration of PTH decreased BP dose dependently. Long-term treatment of SHR/SP with 300 IU PTH s.c. per day clearly attenuated the BP increase. Treatment with PTH was associated with marked hypercalcemia, increased urinary excretion of calcium and cAMP.