Related Experiment Video
Updated: May 31, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Alternatives to potentially inappropriate medications for use in e-prescribing software: triggers and treatment
Anne L Hume1, Brian J Quilliam, Roberta Goldman
1Department of Pharmacy Practice, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA.
Objective:
To describe the development of evidence-based electronic prescribing (e-prescribing) triggers and treatment algorithms for potentially inappropriate medications (PIMs) for older adults.
Design:
Literature review, expert panel and focus group.
Setting:
Primary care with access to e-prescribing systems.
Participants:
Primary care physicians using e-prescribing systems receiving medication history.
Interventions:
Standardised treatment algorithms for clinicians attempting to prescribe PIMs for older patients.
Main Outcome Measure:
Development of 15 treatment algorithms suggesting alternative therapies.
Results:
Evidence-based treatment algorithms were well received by primary care physicians. Providing alternatives to PIMs would make it easier for physicians to change decisions at the point of prescribing.
Conclusion:
Prospectively identifying older persons receiving PIMs or with adherence issues and providing feasible interventions may prevent adverse drug events.
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