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Gout and hyperuricaemia in adults with cystic fibrosis

Alex Horsley1, Jennifer Helm, Amanda Brennan

  • 1Manchester Adult Cystic Fibrosis Centre, Wythenshawe Hospital, Manchester, UK. alex.horsley@nhs.net

Journal of the Royal Society of Medicine
|July 2, 2011
PubMed

Insights

Gout is a newly identified complication in cystic fibrosis (CF) patients. This study found a higher prevalence of gout and elevated serum urate levels in adults with CF.

Area of Science:

  • Nephrology
  • Rheumatology
  • Pulmonology

Background:

  • Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs.
  • Gout, a form of inflammatory arthritis, has not been previously recognized as a complication in CF.

Observation:

  • Nine adult CF patients presented with acute gout symptoms.
  • Serum urate levels were routinely monitored in the CF population.

Findings:

  • The estimated prevalence of gout in the adult CF population is approximately 2.5%, which is higher than the general non-CF population (around 1%).
  • Mean serum urate levels were significantly elevated in both male (0.40 mmol/L) and female (0.31 mmol/L) CF patients compared to historical controls.
  • A substantial percentage of CF patients exhibited hyperuricemia, with 37% of males and 36% of females having serum urate levels above the normal range.

Implications:

  • Gout should be considered as a potential complication in cystic fibrosis patients.
  • Elevated serum urate levels are common in CF and may indicate an increased risk for gout.
  • Further research is warranted to understand the mechanisms linking CF and hyperuricemia/gout.

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