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Published on: February 8, 2017
Niosomes: a controlled and novel drug delivery system
Rampal Rajera1, Kalpana Nagpal, Shailendra Kumar Singh
1Division of Pharmaceutics, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, India.
Biological & Pharmaceutical Bulletin
|July 2, 2011
Summary
Niosomes, a type of non-ionic surfactant vesicle, offer improved drug delivery by controlling release rates and targeting specific sites. This review explores their composition, characterization, and applications in novel drug delivery systems.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Vesicular systems like liposomes and niosomes are increasingly important for enhancing drug delivery.
- Conventional dosage forms often fail to meet the precise delivery requirements of modern therapeutics.
- Niosomes, utilizing non-ionic surfactants, present a promising alternative for controlled and targeted drug administration.
Purpose of the Study:
- To review the composition, characterization, advantages, disadvantages, and applications of niosomes.
- To highlight the role of niosomes in developing novel drug delivery systems (NDDS).
- To explain the formation and structural properties of niosomes.
Main Methods:
- The study involves a comprehensive review of existing literature on niosomes.
- Analysis of niosome composition, including non-ionic surfactants and other excipients.
- Evaluation of niosome characterization techniques and their performance metrics.
Main Results:
- Niosomes are non-ionic surfactant-based vesicles capable of encapsulating aqueous solutions.
- Their formulation allows for controlled drug release, modified distribution profiles, and targeted delivery.
- Niosomes offer advantages over conventional systems in achieving therapeutic goals.
Conclusions:
- Niosomes represent a significant advancement in drug delivery technology.
- Their unique properties enable sustained release and targeted administration, addressing limitations of conventional methods.
- Further research into niosome applications promises enhanced therapeutic outcomes.
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