Related Experiment Video
Updated: May 31, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
[Prospects for the use of histaminergic preparations for the purpose of noise otoprotection]
Abstract:
The objective of the present study was to experimentally evaluate the otoprotective effect of the histaminergic preparation betagistin dihydrochloride given at a dose of 32 mg to 10 healthy male volunteers aged from 18 to 22 (mean 19.4) years who were exposed to 85 dB "white" nose for 1 hour. The functional state of their auditory system was estimated from the results of investigations including determination of the tonal auditory threshold, delayed evoked otoacoustic emission and distortion-product frequency otoacoustic emission, short-latency evoked auditory potentials, and extratympanic electrocochleography. It was shown that betagistin dihydrochloride produced a well-apparent otoprotective effect over the entire range of tests comprehensively characterizing the functional state of the cochlea. It is concluded that betagistin dihydrochloride has good prospects for the application in a variety of production activities (to treat occupational noise-induced pathology) including aerospace medicine.
More Related Videos
09:18A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
Published on: March 8, 2017
06:55A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset (Callithrix jacchus)
Published on: February 27, 2018
Related Concept Videos
Cholinergic Antagonists: Therapeutic Uses
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal secretions in common...
Upper Respiratory Drugs: First and Second-Generation Antihistamines
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Drugs Used in Upper Respiratory Disorders: Overview
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by anesthetizing...