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Related Experiment Video

Updated: May 31, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Tamoxifen-induced hirsutism.

Firas Al-Niaimi¹, C Lyon

¹Department of Dermatology, Salford Royal Hospital Trust, Manchester, UK. firas55@hotmail.com

Journal of Drugs in Dermatology : JDD

|July 2, 2011

Summary

Tamoxifen is an adjuvant therapy for estrogen-receptor positive breast cancer. This case report details a rare side effect: rapid onset hirsutism after tamoxifen administration.

Area of Science:

Oncology
Endocrinology

Background:

Tamoxifen is a selective estrogen receptor modulator (SERM) widely used as adjuvant therapy for estrogen-receptor positive (ER+) breast carcinoma.
Its mechanism of action involves antagonizing estrogen receptors, thereby inhibiting tumor growth.

Observation:

This report describes a case of a patient who developed rapid onset hirsutism.
Hirsutism, characterized by excessive hair growth in a male-like pattern, is a known but uncommon side effect of tamoxifen therapy.

Findings:

The patient experienced a swift development of hirsutism shortly after commencing tamoxifen treatment.
This adverse effect highlights a specific endocrine disruption caused by tamoxifen's anti-estrogenic properties.

Implications:

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Clinicians should be aware of the potential for rapid hirsutism as an adverse effect of tamoxifen.
Monitoring for endocrine-related side effects is crucial in patients undergoing tamoxifen therapy for breast cancer.