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Updated: May 31, 2026
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NiO Nanoflowers for Non-Enzymatic Amperometric Detection of Glucose
Published on: December 30, 2025
Glucose biosensor based on titanium dioxide-multiwall carbon nanotubes-chitosan composite and functionalized gold
Meihe Zhang1, Ruo Yuan, Yaqin Chai
1Key Education Ministry Laboratory on Luminescence and Real-Time Analysis, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.
Bioprocess and Biosystems Engineering
|July 2, 2011
Summary
A novel glucose biosensor was developed using Prussian blue, gold nanoparticles, and glucose oxidase immobilized on a composite electrode. This biosensor demonstrates excellent performance for glucose detection, showing potential for future diagnostic applications.
Area of Science:
- Electrochemistry
- Nanomaterials Science
- Biosensor Technology
Background:
- Development of sensitive and selective glucose biosensors is crucial for diabetes management.
- Nanomaterials offer unique properties for enhancing biosensor performance.
- Previous biosensor designs have limitations in sensitivity and stability.
Purpose of the Study:
- To fabricate a novel electrochemical biosensor for glucose detection.
- To investigate the synergistic effects of composite nanomaterials on biosensor performance.
- To characterize the electrochemical properties and fabrication process of the proposed biosensor.
Main Methods:
- Fabrication of a multi-layered electrode using Prussian blue, TiO(2)-MWNTs-CS composite, and PDDA-Au nanoparticles.
- Electrochemical characterization using cyclic voltammetry (CV) and amperometry.
- Morphological and structural analysis using scanning electron microscopy (SEM), UV-Vis spectroscopy, and transmission electron microscopy (TEM).
Main Results:
- The stepwise fabrication process was successfully achieved and characterized.
- The developed glucose biosensor showed a linear detection range from 6 μM to 1.2 mM.
- A low detection limit of 0.1 μM glucose (S/N=3) was achieved.
- The composite materials demonstrated significant potential for biosensor construction.
Conclusions:
- The novel glucose biosensor exhibits high sensitivity and a wide linear range.
- The combination of TiO(2)-MWNTs-CS composite and PDDA-Au nanoparticles is promising for advanced biosensor development.
- This work contributes to the field of electrochemical biosensors for glucose monitoring.
