Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

Diabetes Mellitus: Type 2 and Gestational

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

Pathophysiology of Diabetes

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association of Prenatal Exposure to Maternal Drinking and Smoking With the Risk of Stillbirth.

JAMA network open·2021

Same author

Concurrent prenatal drinking and smoking increases risk for SIDS: Safe Passage Study report.

EClinicalMedicine·2020

Same author

Home Monitoring for Fetal Heart Rhythm During Anti-Ro Pregnancies.

Journal of the American College of Cardiology·2018

Same author

Pregnancy and vaccines.

South Dakota medicine : the journal of the South Dakota State Medical Association·2013

Same author

Second-trimester abortion for fetal anomalies or fetal death: labor induction compared with dilation and evacuation.

Obstetrics and gynecology·2011

Same author

First-trimester genetic diagnosis: a series of six cases.

South Dakota medicine : the journal of the South Dakota State Medical Association·2010

Same journal

2025 Scholars' Research Symposium Abstract: Influence of Disability Education, Panel Discussion on Comfort and Knowledge of Healthcare Providers in South Dakota.

South Dakota medicine : the journal of the South Dakota State Medical Association·2025

Same journal

2025 Scholars' Research Symposium Abstract: Improving Interactions During Medical Interpretation: An Educational Module for Medical Students.

South Dakota medicine : the journal of the South Dakota State Medical Association·2025

Same journal

2025 Scholars' Research Symposium Abstract: Walk With Ease Benefiting South Dakota.

South Dakota medicine : the journal of the South Dakota State Medical Association·2025

Same journal

2025 Scholars' Research Symposium Abstract: Ultrasonographic Accuracy in Rural vs Urban Counties.

South Dakota medicine : the journal of the South Dakota State Medical Association·2025

Same journal

2025 Scholars' Research Symposium Abstract: Minimizing Grief and Loss Through Advanced Care Planning.

South Dakota medicine : the journal of the South Dakota State Medical Association·2025

Same journal

2025 Scholars' Research Symposium Abstract: Food Security During Pregnancy and Adverse Birth Outcomes.

South Dakota medicine : the journal of the South Dakota State Medical Association·2025

See all related articles

Search research articles

Related Experiment Video

Updated: May 31, 2026

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

Published on: September 27, 2017

Obesity in pregnancy.

Peter Van Eerden¹

¹Department of OB/GYN, Sanford School of Medicine, University of South Dakota, USA.

South Dakota Medicine : the Journal of the South Dakota State Medical Association

|July 2, 2011

Summary

This summary is machine-generated.

Obesity affects over a third of U.S. women and is linked to pregnancy complications and childhood obesity. This review covers obesity

More Related Videos

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

Related Experiment Videos

Last Updated: May 31, 2026

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

Published on: September 27, 2017

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

Area of Science:

Obstetrics and Gynecology
Public Health
Pediatrics

Background:

Over one-third of U.S. women are obese, with rising childhood obesity rates.
Obesity and excessive gestational weight gain are independent risk factors for maternal and fetal complications.
These factors may contribute to the current epidemic of childhood obesity.

Purpose of the Study:

To review the effects of obesity on pregnancy.
To discuss potential prevention methods for obesity-related pregnancy complications.

Main Methods:

Literature review of existing studies on obesity and pregnancy.
Analysis of risk factors and complications associated with maternal obesity.
Examination of the link between maternal obesity, fetal outcomes, and childhood obesity.

Main Results:

Obesity is associated with increased risks of miscarriage, infertility, and congenital anomalies.
Excessive gestational weight gain contributes to late-pregnancy complications and fetal macrosomia.
Fetal macrosomia is a risk factor for the development of childhood obesity.

Conclusions:

Maternal obesity poses significant risks to both mother and fetus during pregnancy.
Preventing obesity and managing gestational weight gain are crucial for mitigating pregnancy complications.
Addressing maternal obesity is essential for combating the childhood obesity epidemic.