Evaluation of the relationship between insulin resistance and recurrent pregnancy loss

To investigate insulin resistance in patients with recurrent pregnancy loss (RPL).

Single center, case-control, prospective study.

The study was performed at the Obstetrics and Gynecology Clinic at the Dicle University Medical Faculty from May to October 2009. 64 study subjects who had RPL were compared to 64 controls. Both groups were compared with fasting glucose, fasting insulin, fasting glucose/fasting insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) index values to assess insulin resistance.

No significant differences in age and BMI index were found between the study and control subjects (p > 0.005). The mean number of abortions was 3.04 in the study and 0.2 in the control group (p < 0.001). The mean fasting glucose value was 100.84 in the study group, and 89.67 in the control group (p < 0.001). Also, the mean fasting insulin value was 15.51 in the study group and 7.17 in the control group (p = 0.001). The mean glucose/ insulin ratio was 12.24 in the study group and 28.27 in the control group (p = 0.017), and the mean HOMA-IR value was 4.16 in the study group and 1.62 in the control group (p = 0.002).

Compared with the control group, patients with RPL were more likely to have insulin resistance.