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Updated: May 31, 2026

Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses
Published on: May 9, 2021
Time-delay-induced phase-transition to synchrony in coupled bursting neurons
Bhim Mani Adhikari1, Awadhesh Prasad, Mukeshwar Dhamala
1Department of Physics and Astronomy, Georgia State University, Atlanta, Georgia 30303, USA.
Abstract:
Signal transmission time delays in a network of nonlinear oscillators are known to be responsible for a variety of interesting dynamic behaviors including phase-flip transitions leading to synchrony or out of synchrony. Here, we uncover that phase-flip transitions are general phenomena and can occur in a network of coupled bursting neurons with a variety of coupling types. The transitions are marked by nonlinear changes in both temporal and phase-space characteristics of the coupled system. We demonstrate these phase-transitions with Hindmarsh-Rose and Leech-Heart interneuron models and discuss the implications of these results in understanding collective dynamics of bursting neurons in the brain.
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