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Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis
Published on: October 17, 2016
Development of a catadioptric endoscope objective with forward and side views
Roy Chih Chung Wang1, M Jamal Deen, David Armstrong
1McMaster University, Department of Engineering Physics, 1280 Main Street West, Hamilton, Ontario, L8S 4L7, Canada.
Journal of Biomedical Optics
|July 5, 2011
Summary
Autofluorescence endoscopy uses a novel radial-view objective lens to improve light collection for early gastrointestinal cancer detection. This new design enhances imaging of faint autofluorescence signals, crucial for screening pre-cancerous lesions.
Area of Science:
- Biomedical optics
- Gastroenterology
- Medical imaging
Background:
- Autofluorescence endoscopy (AFE) is a functional imaging technique for detecting gastrointestinal (GI) pre-cancerous and early cancer lesions.
- Tissue autofluorescence signals are inherently weak, posing challenges for conventional forward-viewing endoscopes with limited light collection efficiency.
- Efficient light collection is critical for AFE, necessitating advancements in endoscope objective design.
Purpose of the Study:
- To design, optimize, and develop a novel endoscope objective capable of simultaneous forward and radial imaging for improved autofluorescence collection.
- To enhance the light-gathering capability for weak autofluorescence signals in GI tract screening.
- To validate simulation methods for optical design through prototype testing.
Main Methods:
- Design and optimization of a radial-view optical system balancing image quality and light collection efficiency.
- Utilized modulation transfer function (MTF), entrance pupil radius, manufacturability, and field-of-view as key optimization parameters.
- Employed nonsequential ray trace simulations to predict performance and validated with a 3:1 scaled-up prototype, comparing contrast measurements with simulated MTF.
Main Results:
- The proposed radial-view endoscope objective design demonstrates superior light collection efficiency compared to conventional forward-viewing endoscopes, as indicated by simulations.
- A scaled-up prototype was successfully fabricated, allowing for experimental validation of the optical design and simulation methods.
- Contrast measurements from the prototype correlated well with simulated modulation transfer function (MTF) values, confirming the design's effectiveness.
Conclusions:
- The developed radial-view endoscope objective is a practical advancement for autofluorescence endoscopy, significantly improving light collection for GI cancer screening.
- The study validates the use of nonsequential ray tracing simulations for optimizing optical designs in functional endoscopic imaging.
- This improved light collection capability holds promise for earlier and more accurate detection of pre-cancerous and early-stage GI malignancies.
