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Effects of exercise on insulin-induced hypoglycemia
J Arogyasami1, R K Conlee, C L Booth
1Department of Zoology, Brigham Young University, Provo, Utah 84602.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 1, 1990
Summary
Exercise accelerates hypoglycemia in fed rats but not fasted rats. Muscle glycogen replenishment occurred post-exercise in fed rats despite falling blood glucose levels.
Area of Science:
- Exercise physiology
- Metabolic regulation
- Endocrinology
Background:
- Hypoglycemia is a common complication of insulin therapy.
- The role of exercise in modulating insulin-induced hypoglycemia requires further investigation.
- Fasted and fed states may influence the body's response to exercise during insulin infusion.
Purpose of the Study:
- To determine the effect of exercise on the onset rate of insulin-induced hypoglycemia.
- To compare the effects of exercise in fasted versus fed rats.
- To assess muscle glycogen repletion following exercise during insulin infusion.
Main Methods:
- Rats were subjected to overnight fasting (FS) or fed ad libitum (FD).
- Insulin infusion (0.8 mU.min-1.100 g-1) was administered at rest or during treadmill exercise.
- Blood glucose levels and muscle glycogen content were measured at various time points.
Main Results:
- Exercise did not alter the rate of hypoglycemia in fasted rats.
- Fed rats exhibited significantly lower blood glucose levels after 40 minutes of exercise during insulin infusion.
- Significant postexercise muscle glycogen repletion was observed in fed rats despite declining blood glucose.
Conclusions:
- Exercise accelerates the development of hypoglycemia in fed rats.
- Exercise does not affect the time course of hypoglycemia in fasted rats.
- Fed rats demonstrate enhanced muscle glycogen storage post-exercise even with decreasing blood glucose.
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