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Increasing prevalence of coeliac disease in Denmark: a linkage study combining national registries
Stine Dydensborg1, Peter Toftedal, Matteo Biaggi
1Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense C, Denmark.
Insights
The prevalence of diagnosed coeliac disease (CD) in Danish children and adolescents has significantly increased over a 15-year period. This trend highlights a growing need for awareness and early diagnosis of CD in pediatric populations.
Area of Science:
- Pediatric Gastroenterology
- Epidemiology
- Public Health
Background:
- Coeliac disease (CD) is a significant autoimmune disorder affecting children and adolescents.
- Understanding the epidemiological trends of CD is crucial for public health planning and resource allocation.
Purpose of the Study:
- To determine the prevalence and incidence of diagnosed coeliac disease (CD) in Danish children and adolescents.
- To analyze temporal trends in CD diagnosis and associated factors over a 15-year period.
Main Methods:
- Utilized data from the Danish National Patient Registry (DNPR) for CD diagnoses.
- Validated diagnoses using small-bowel biopsy data from the National Registry of Pathology (NRP) and hospital records.
- Analyzed data spanning from 1996 to 2010.
Main Results:
- Registered CD prevalence in children increased from 43.2 to 83.6 per 100,000.
- Registered CD incidence rose from 2.8 to 10.0 per 100,000.
- Biopsy-verified CD incidence increased significantly, and the mean age at diagnosis rose to 8.1 years.
Conclusions:
- The prevalence of diagnosed coeliac disease in Danish children and adolescents has notably increased over the past 15 years.
- This upward trend indicates a growing burden of coeliac disease in the pediatric population.
Aim:
To determine the prevalence and incidence of diagnosed coeliac disease (CD) in Danish children and adolescents and to describe trends over time.
Methods:
All children with a CD diagnosis registered in the Danish National Patient Registry (DNPR) were included in the study. Data were validated by combining this information with registrations of small-bowel biopsies in the National Registry of Pathology (NRP) and with a selected sample of hospital records.
Results:
Data were obtained from 1996 to 2010. The prevalence of CD registered in DNPR increased from 43.2 [95% CI 39.3-47.1] to 83.6 [95% CI 78.4-88.7] per 100,000, and the incidence increased from 2.8 [95% CI 1.9-3.9] to 10.0 [95% CI 8.4-12.0] per 100,000; 56% of the children had at least one biopsy compatible with CD registered in NRP. The incidence of biopsy-verified CD increased from 0.8 [95% CI 0.3-1.4] to 6.9 [95% CI 5.4-8.4] per 100,000. The mean age at diagnosis increased from 5.1 [95% CI 3.5-6.6] to 8.1 [95% CI 7.2-9.0] years of age. The proportion of children with associated diseases did not change over time.
Conclusion:
The prevalence of diagnosed CD in Danish children and adolescents has increased over the last 15 years.
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