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Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Diabetes Mellitus: Introduction01:26

Diabetes Mellitus: Introduction

Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...

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Improved Protocol For Laser Microdissection Of Human Pancreatic Islets From Surgical Specimens
09:43

Improved Protocol For Laser Microdissection Of Human Pancreatic Islets From Surgical Specimens

Published on: January 6, 2013

DIAMAP: a road map for diabetes research in Europe.

Sarah Hills1, Philippe A Halban

  • 1EURADIA, Düsseldorf, Germany. sarah.hills@euradia.org

Journal of Diabetes Science and Technology
|July 5, 2011
PubMed
Summary

The DIAMAP Project has concluded, offering a strategic roadmap for European diabetes research. Its findings, including a report and databases, guide future research activities and investments.

Area of Science:

  • Endocrinology and Metabolic Diseases
  • Public Health Policy
  • Research Strategy

Background:

  • Diabetes poses a significant health burden in Europe, necessitating coordinated research efforts.
  • Previous research strategies lacked a unified, European-wide approach.
  • The need for a comprehensive roadmap to guide diabetes research investment and activity was identified.

Purpose of the Study:

  • To develop a strategic roadmap for diabetes research in Europe.
  • To provide guidance for research activity and investment.
  • To integrate the perspective of people with diabetes into research planning.

Main Methods:

  • The DIAMAP Project involved drawing up a comprehensive roadmap for diabetes research.
  • Results are disseminated through a final report and accessible, searchable databases.

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  • A broad approach to research, centered on the needs of individuals with diabetes, was adopted.

    • Main Results:

    • The DIAMAP Project has concluded, delivering its final roadmap.
    • A comprehensive report detailing the roadmap is available.
    • Searchable databases containing relevant information have been established.

    Conclusions:

    • The DIAMAP roadmap provides strategic direction for European diabetes research.
    • Future research investment and activity in Europe will be guided by this roadmap.
    • The project emphasizes a patient-centered and broad research approach.