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Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Goodpasture's disease complicating human immunodeficiency virus infection
P Singh1, M Barry, A Tzamaloukas
1Division of Nephrology, UNM Health Sciences Center, University of New Mexico, Albuquerque, NM 87131, USA. psingh@salud.unm.edu
Clinical Nephrology
|July 5, 2011
Summary
Goodpasture
Area of Science:
- Nephrology
- Immunology
- Infectious Diseases
Background:
- Goodpasture's disease is a rare autoimmune disorder.
- Association between Goodpasture's disease and human immunodeficiency virus (HIV) is exceptionally uncommon.
Observation:
- A 33-year-old male with HIV and hepatitis C presented with anuria, hyperkalemia, and elevated creatinine.
- Renal biopsy confirmed anti-glomerular basement membrane crescentic glomerulonephritis with linear IgG deposition.
Findings:
- Initial treatment with plasmapheresis and steroids did not restore renal function.
- Pulmonary hemorrhage developed, prompting plasmapheresis and cyclophosphamide, which improved respiratory symptoms but not renal function.
- The patient required long-term hemodialysis.
Implications:
- Co-occurrence of Goodpasture's syndrome and HIV presents significant diagnostic and therapeutic challenges.
- Immunosuppressive therapy in HIV-infected patients necessitates heightened vigilance for opportunistic infections.
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