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Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
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Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

Factors associated with multidrug-resistant Acinetobacter transmission: an integrative review of the literature

Denise Moultrie1, Jeremy Hawker, Shannon Cole

  • 1Department of Anesthesia and Operative Services, Brooke Army Medical Center, Fort Sam Houston, TX, USA.

AORN Journal
|July 5, 2011
PubMed

Insights

Multidrug-resistant Acinetobacter infections are rising in war wounds. This review identifies transmission factors and prevention strategies for Acinetobacter Baumannii in military settings.

Area of Science:

  • Infectious Diseases
  • Military Medicine
  • Public Health

Background:

  • Multidrug-resistant (MDR) Acinetobacter infections pose a significant threat in the context of traumatic war injuries.
  • The specific causative factors contributing to the alarming rates of these infections remain largely unidentified.

Purpose of the Study:

  • To identify factors associated with the transmission of multidrug-resistant Acinetobacter in the context of war-related injuries.
  • To synthesize current knowledge on transmission routes and prevention strategies for MDR Acinetobacter in military populations.

Main Methods:

  • An integrative literature review was conducted using the Identifying, Organizing, and Synthesizing strategy.
  • The review focused on identifying common themes related to MDR Acinetobacter transmission, including wound types, risk factors, contributing factors, modes of transmission, and prevention strategies.

Main Results:

  • Five major themes of commonality regarding transmission were identified.
  • Key transmission sources, such as environmental contamination and healthcare worker contact, were highlighted.
  • Effective interventions including strict infection control, judicious antibiotic use, and patient notification were identified.

Conclusions:

  • Understanding transmission dynamics is crucial for controlling MDR Acinetobacter in military settings.
  • Replication of identified studies in military populations is recommended to validate findings.
  • Implementing targeted interventions can reduce healthcare-associated and surgical site MDR Acinetobacter infections.

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