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Atherogenic lipid profile in Behçet's disease: evidence of alteration of HDL subclasses

Meriam Messedi1, Kamel Jamoussi, Makram Frigui

  • 1Research Unit, Molecular Bases of Human Diseases, Sfax College of Medicine, Sfax, Tunisia. meriammessedi@yahoo.fr

Archives of Medical Research
|July 5, 2011
PubMed

Insights

Behçet

Area of Science:

  • Cardiovascular Research
  • Inflammatory Diseases
  • Lipid Metabolism

Background:

  • Behçet's disease (BD) is a chronic inflammatory vasculitis.
  • Accelerated atherosclerosis is a concern in BD patients.
  • The link between cardiovascular risk factors and atherosclerosis in BD is debated.

Purpose of the Study:

  • To assess lipid profiles in BD patients.
  • To investigate low-density lipoprotein (LDL) size in BD.
  • To analyze high-density lipoprotein (HDL) subpopulation distribution in BD.

Main Methods:

  • Compared 36 BD patients with 36 healthy controls.
  • Measured total cholesterol, triglycerides, and HDL-cholesterol.
  • Assessed HDL subclasses and LDL size using electrophoresis; measured hsCRP and homocysteine.

Main Results:

  • BD patients showed reduced HDL-cholesterol and HDL2, with increased HDL3.
  • The LDL-C/HDL-C ratio and hsCRP levels were elevated in BD patients.
  • Correlations found between lipid levels, hsCRP, triglycerides, and age.

Conclusions:

  • Reduced HDL-C and HDL2, increased HDL3, and higher LDL-C/HDL-C ratio are potential cardiovascular event predictors in BD.
  • These lipid alterations may signify increased cardiovascular risk in Behçet's disease.
  • Further research into cardiovascular risk stratification in BD is warranted.
Abstract

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