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Meta-analysis of MMP2 -1306T allele as a protective factor in digestive cancer
1Department of Gastroenterology, Ninth Peoples Hospital, Wuxi, Jiangsu, China. meta-analysis2011@hotmail.com
Background And Aims:
Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity on matrix proteins and abolishes a Sp-1 binding site and consequently decreases its activity. Many studies have been carried out on the association between MMP2 -1306C/T polymorphism and digestive cancer risk, but results were somewhat controversial and underpowered.
Methods:
To examine the risk of digestive cancer associated with -1306C/T polymorphism of MMP2, we performed a meta-analysis of ten case-control studies. Eligible studies were identified by searching the electronic literature using Pubmed and Embase. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association.
Results:
Overall, we found that -1306T allele can decrease digestive cancer risk in three different genotype models (T-allele vs. C-allele, OR=0.73, 95% CI: 0.54-0.98, p=0.034; TC vs. CC, OR=0.64, 95% CI: 0.53-0.78, p <0.001; TT+TC vs. CC, OR=0.68, 95% CI: 0.53-0.86, p=0.002). Similarly, in the stratified analysis by cancer type, ethnicity and source of control, significantly decreased cancer risk was indicated. Moreover, in the subgroup of smokers, -1306T allele may protect people against digestive cancer risk (TT+TC vs. CC, OR=0.71, 95% CI: 0.51-0.98, p=0.037).
Conclusions:
Our meta-analysis showed evidence that MMP2 -1306T allele may be a protective factor for digestive cancer risk as well as a low-penetrance susceptibility digestive cancer biomarker.
Insights
The T allele of the Matrix metalloproteinase-2 (MMP-2) -1306C/T polymorphism may reduce digestive cancer risk. This MMP2 genetic variant shows potential as a low-penetrance biomarker for digestive cancer susceptibility.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Matrix metalloproteinase-2 (MMP-2) is an enzyme involved in matrix protein degradation.
- Previous studies on the association between MMP2 -1306C/T polymorphism and digestive cancer risk have yielded controversial and underpowered results.
Purpose of the Study:
- To investigate the association between the MMP2 -1306C/T polymorphism and the risk of developing digestive cancers.
- To clarify the controversial findings from previous studies through a comprehensive meta-analysis.
Main Methods:
- A meta-analysis was conducted on ten case-control studies.
- Studies were identified through searches of PubMed and Embase electronic databases.
- Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the risk association.
Main Results:
- The -1306T allele of MMP2 was associated with a decreased risk of digestive cancer across multiple genotype models.
- Stratified analyses by cancer type, ethnicity, and control source consistently indicated a reduced cancer risk.
- A protective effect of the -1306T allele was observed in smokers.
Conclusions:
- The MMP2 -1306T allele demonstrates a protective effect against digestive cancer.
- This genetic variant may serve as a low-penetrance biomarker for digestive cancer susceptibility.
