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Related Experiment Video

Updated: May 31, 2026

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

P11 expression and PET in bipolar disorders.

Lei Zhang¹, Cheng-Ta Li, Tung-Ping Su

¹Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Lezhang@USUHS.mil

Journal of Psychiatric Research

|July 5, 2011

Summary

Peripheral blood mononuclear cell (PBMC) p11 mRNA levels correlate with brain glucose metabolism in bipolar disorder (BD) patients. This finding suggests p11 mRNA may serve as a biomarker for BD, particularly for tracking depressive episodes.

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Published on: October 10, 2012

Area of Science:

Neuroscience
Biomarkers
Psychiatry

Background:

Bipolar disorder (BD) is a prevalent mental health condition with subtypes BD-I and BD-II.
Current diagnostic methods lack specific biomarkers to differentiate between BD-I and BD-II.
Peripheral blood mononuclear cell (PBMC) p11 mRNA levels and positron emission tomography (PET) are explored as potential BD biomarkers.

Purpose of the Study:

To investigate the relationship between PBMC p11 mRNA levels and brain glucose metabolism in BD patients.
To explore the potential of PBMC p11 mRNA as a biomarker for differentiating BD subtypes and correlating with illness severity.

Main Methods:

A resting PET study using [(18)F]-2-deoxy-2-fluoro-d-glucose ((18)F-FDG) was conducted on 60 participants (20 healthy controls, 20 BD-I, 20 BD-II).
PBMC p11 mRNA levels were quantified using real-time PCR.
Normalized glucose metabolism (NGM) was analyzed in various brain regions.

Main Results:

BD patients exhibited altered NGM in several brain regions compared to controls, including the hippocampus, amygdala, and prefrontal cortex.
BD-I patients showed distinct patterns of hypometabolism and hypermetabolism compared to BD-II patients.
PBMC p11 mRNA was overexpressed in both BD subtypes and positively correlated with NGM in specific brain areas and the number of depressive episodes.

Conclusions:

PBMC p11 mRNA expression is linked to neural activity in the brains of bipolar disorder patients.
These findings support the potential clinical utility of PBMC p11 mRNA as a biomarker for BD.
Further translational research is recommended to validate these results in larger cohorts.