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Related Experiment Videos

Growth hormone response to prostaglandin E2.

W Hamilton, D M Hussein

    Acta Paediatrica Scandinavica
    |March 1, 1979
    PubMed
    Summary

    Prostaglandin E2 (PGE2) can stimulate growth hormone release directly from the pituitary. This offers a safer alternative to insulin hypoglycemia testing for assessing growth hormone secretion.

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    Area of Science:

    • Endocrinology
    • Neuroendocrinology

    Background:

    • Cyclic adenosine monophosphate (C-AMP) mediates growth hormone (GH) release from the pituitary gland.
    • Prostaglandin E2 (PGE2) increases pituitary adenylate cyclase and C-AMP, suggesting it functions as a growth hormone-releasing hormone.

    Purpose of the Study:

    • To evaluate the efficacy of PGE2 as a stimulus for GH release.
    • To compare the GH response to PGE2 with the response to insulin-induced hypoglycemia.
    • To assess the safety profile of PGE2 compared to insulin hypoglycemia testing.

    Main Methods:

    • Intravenous administration of PGE2 (30 µg/kg body weight) in patients.
    • Assessment of growth hormone levels following PGE2 administration.
    • Comparison with growth hormone response to insulin-induced hypoglycemia in the same patients.

    Main Results:

    • In patients unresponsive to insulin hypoglycemia, PGE2 elicited a significant GH rise in 6 out of 18 cases.
    • When PGE2 failed to stimulate GH release, there was no GH response to insulin-induced hypoglycemia.
    • PGE2 administration did not induce hypoglycemia; instead, it caused a slight increase in plasma glucose levels.

    Conclusions:

    • PGE2 acts directly on the pituitary to release preformed GH, bypassing potential hypothalamic dysfunction.
    • PGE2 is a viable alternative to insulin hypoglycemia for assessing pituitary GH secretory capacity.
    • PGE2 avoids the risk of hypoglycemia-associated brain damage inherent in the insulin tolerance test.

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