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Giant eccrine acrospiroma.

S J Hunt1, D J Santa Cruz, H Kerl

  • 1Department of Cutaneous Pathology, St. John's Mercy Medical Center, St. Louis, MO 63141-8221.

Journal of the American Academy of Dermatology
|October 1, 1990
PubMed
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Large eccrine acrospiromas, both benign and malignant, were analyzed. Key distinctions for benign tumors include circumscription and lack of invasion, aiding in differentiating them from malignant counterparts.

Area of Science:

  • Dermatopathology
  • Oncology
  • Surgical Pathology

Background:

  • Eccrine acrospiromas are skin tumors originating from sweat glands.
  • Large eccrine acrospiromas can present diagnostic challenges, particularly in distinguishing benign from malignant forms.

Purpose of the Study:

  • To report and analyze four cases of large eccrine acrospiromas, including three benign and one malignant.
  • To identify key histopathological features that differentiate benign from malignant large eccrine acrospiromas.

Main Methods:

  • Retrospective analysis of four surgically resected large eccrine acrospiromas.
  • Histopathological examination focusing on cellular atypia, mitotic activity, and invasion patterns.
  • Comparison of features between benign and malignant cases.

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Main Results:

  • Three benign eccrine acrospiromas occurred on the lower extremities of elderly individuals, present for 10-20 years.
  • One malignant eccrine acrospiroma was on the chest of a 60-year-old man, possibly arising from a long-standing lesion.
  • Cellular atypia was minimal in all cases; mitotic rates did not reliably distinguish benign from malignant tumors.

Conclusions:

  • Relative circumscription, lack of cellular atypia, and absence of stromal, perineurial, and angiolymphatic invasion are crucial for diagnosing benign large eccrine acrospiromas.
  • These features are essential for differentiating benign eccrine acrospiromas from their malignant counterparts, guiding appropriate clinical management.