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Related Experiment Video

Updated: May 31, 2026

Blood Flow Imaging with Ultrafast Doppler

Blood Flow Imaging with Ultrafast Doppler

Published on: October 14, 2020

Ultrasound contrast imaging based on a novel algorithm combined pulse inversion with wavelet transform.

Xiaoyan Zhao¹, Hui Zhong, Mingxi Wan

¹The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, P.R. China.

Ultrasound in Medicine & Biology

|July 5, 2011

Summary

This study introduces a novel ultrasound contrast imaging method using pulse inversion and wavelet transform to improve bubble visualization. The technique enhances contrast-to-tissue ratio by up to 28 dB, aiding in clearer imaging of microbubbles.

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Area of Science:

Medical Imaging
Biomedical Engineering
Acoustics

Background:

Ultrasound contrast imaging utilizes microbubbles to enhance echogenicity.
Pulse-inversion techniques are established for non-linear signal extraction.
Wavelet transform offers advanced signal processing capabilities for echo analysis.

Purpose of the Study:

To develop an advanced ultrasound contrast imaging method.
To enhance the contrast-to-tissue ratio (CTR) for microbubble visualization.
To improve the suppression of surrounding tissue signals.

Main Methods:

A novel ultrasound contrast imaging method combining pulse-inversion and wavelet transform.
Utilizing a custom-designed "bubble wavelet" based on the modified Herring equation.
Acquiring radio-frequency (RF) data using a modified digital diagnostic ultrasound system with dual inverted pulses.

Main Results:

Simulations validated the proposed method.
Experiments on an ultrasound flow phantom showed a CTR improvement of up to 28 dB compared to pulse-inversion-based second-harmonic imaging.
In vivo rabbit kidney experiments demonstrated effective suppression of surrounding tissue signals relative to microbubble signals.

Conclusions:

The proposed ultrasound contrast imaging method significantly improves CTR.
The technique effectively visualizes microbubbles while suppressing tissue interference.
Further optimization of the "bubble wavelet" and imaging algorithm may yield additional improvements.