Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A cross-sectional exploration of the relationship between Parkinson's disease and peripheral blood immune cells in an ethnically diverse East London population.

Journal of the neurological sciences·2026
Same author

The rate of non-sentinel lymph node metastases at axillary dissection in patients with a positive sentinel lymph node after neoadjuvant chemotherapy.

Surgical oncology·2026
Same author

Frequency of workplace incidents and injuries in veterinarians, veterinary nurses and veterinary students and measures to control these.

Australian veterinary journal·2024
Same author

Enhanced charge density wave coherence in a light-quenched, high-temperature superconductor.

Science (New York, N.Y.)·2022
Same author

Serum angiotensin converting enzyme elevation in association with artificial stone silicosis.

Respiratory medicine·2021
Same author

COVID-19: Spatial resolution of excess mortality in Germany and Italy.

The Journal of infection·2020

Related Experiment Video

Updated: May 31, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Hypotheses for mechanisms linking shiftwork and cancer.

L Fritschi1, D C Glass, J S Heyworth

  • 1Western Australian Institute for Medical Research, School of Population Health, The University of Western Australia, Perth, Western Australia, Australia. fritschi@waimr.uwa.edu.au

Medical Hypotheses
|July 5, 2011
PubMed
Summary

Shift work may increase cancer risk through multiple pathways beyond melatonin disruption. Investigating sleep, lifestyle, and vitamin D is crucial for prevention strategies.

More Related Videos

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Related Experiment Videos

Last Updated: May 31, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Area of Science:

  • Occupational Health
  • Cancer Epidemiology
  • Chronobiology

Background:

  • Shift work is linked to adverse health outcomes, including potential cancer risk.
  • Epidemiologic studies show weak associations, hindered by methodological challenges and unclear mechanisms.
  • Reduced melatonin due to light at night is a proposed mechanism, but evidence suggests multiple factors are involved.

Purpose of the Study:

  • To propose additional biological and lifestyle mechanisms linking shift work to cancer risk.
  • To encourage comprehensive investigation of these pathways for effective prevention.
  • To address the impact of shift work on the approximately 20% of the population engaged in it.

Main Methods:

  • Review and proposal of potential mechanisms beyond melatonin reduction.
  • Consideration of circadian disruption (phase shift), sleep disruption, lifestyle factors, and vitamin D levels.
  • Emphasis on a multi-factorial approach to understanding shift work's health effects.

Main Results:

  • Identified four additional plausible mechanisms: phase shift, sleep disruption, lifestyle factors (diet, activity, BMI), and lower vitamin D.
  • Highlighted the need to consider these factors alongside melatonin disruption.
  • Suggested that multiple interacting factors contribute to adverse health outcomes from shift work.

Conclusions:

  • A comprehensive understanding of shift work's impact requires investigating multiple pathways.
  • Effective preventative workplace strategies necessitate considering phase shift, sleep, lifestyle, and vitamin D.
  • Modifying aspects of shift work and identifying individual susceptibility can aid prevention.