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Updated: May 31, 2026
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
The innate immune system in transplantation
Martin H Oberbarnscheidt1, Daniel Zecher, Fadi G Lakkis
1Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA. oberbarnscheidtmh@upmc.edu
The innate immune system identifies microbes via pattern recognition receptors. This review explores if these, along with
Area of Science:
- Immunology
- Transplantation Biology
Background:
- The innate immune system is the primary defense against pathogens.
- It recognizes microbial non-self using specific molecular mechanisms.
- Recognition of non-microbial non-self, like organ transplants, is less understood.
Purpose of the Study:
- To review innate immune recognition mechanisms.
- To explore their applicability to allograft rejection.
- To understand 'damaged' self recognition.
Main Methods:
- Review of pattern recognition receptors (PRRs).
- Analysis of the 'missing self' theory.
- Examination of the 'danger' hypothesis.
Main Results:
- PRRs are key to microbial recognition.
- 'Missing self' and 'danger' hypotheses offer frameworks for non-self recognition.
- These mechanisms may play a role in allograft rejection.
Conclusions:
- Innate immune recognition mechanisms are complex.
- Understanding 'damaged' self recognition is crucial for transplantation.
- Further research is needed to clarify the role of innate immunity in allograft rejection.
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