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Updated: May 31, 2026

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency
Published on: February 2, 2024
Adenocarcinoma arising in an ectopic mediastinal pancreas
Paul St Romain1, Gregory Muehlebach, Ivan Damjanov
1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Abstract:
Pancreatic ectopia in the mediastinum is rare, and there are no reports that it has ever given rise to malignancy. Here we report a case of adenocarcinoma arising in ectopic pancreatic tissue in the mediastinum of a 66-year-old woman. The tumor arose in a partially cystic and partially solid ectopic pancreas containing both exocrine and endocrine components. Thorough clinical examination and clinical follow-up did not reveal other primary sites. The tumor was partially resected but metastasized to the anterior sternum 6 months later and was re-excised. No other similar cases of primary mediastinal pancreatic adenocarcinoma are on record in medical literature.
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