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Updated: May 31, 2026

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
Published on: May 20, 2020
Mutations in EGFR signal pathway in correlation with response to treatment of head and neck cancers
J Neuwirthová1, S Pavel, J Rottenberg
1Clinic of Otorhinolaryngology and Head and Neck Surgery, Masaryk University and St. Anne's Faculty Hospital in Brno, Czech Republic. janeuwi@gmail.com
Unlabelled:
The prognostic and predictive value of the epidermal growth factor receptor (EGFR) expression and some genetic alterations in an EGFR signal pathway, such as the EGFR amplification, the EGFR activating tyrosine kinase domain mutations or the k-ras gene mutation were investigated in our study. The aim of the research was to evaluate the occurrence of the above-mentioned biomarkers in correlation with a therapeutic response and survival in patients with locoregionally advanced spinocellular head and neck cancers.
Keywords:
Head and neck cancer, EGFR, predictive marker, k-ras, EGFR amplification, EGFR tyrosine kinase domain mutation.
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