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Updated: May 31, 2026

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
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Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation

Bin Wu1, Gabriela E Davey, Alexey A Nazarov

  • 1Division of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.

Nucleic Acids Research
|July 5, 2011
PubMed
Summary

Platinum drugs target DNA by binding to guanine bases. DNA structure influences drug binding and effectiveness, impacting cancer therapy development.

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