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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Related Experiment Video

Updated: May 31, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

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Multiple myeloma: diagnosis and orthopaedic implications.

Thomas J Scharschmidt1, Joshua D Lindsey, Pamela S Becker

  • 1Department of Orthopaedic, Ohio State University College of Medicine, Columbus, OH, USA.

The Journal of the American Academy of Orthopaedic Surgeons
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Multiple myeloma, a cancer affecting bones, often leads to pathologic fractures. Treatment requires collaboration between orthopaedic surgeons and oncologists for optimal patient outcomes.

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Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
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Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Published on: January 7, 2019

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Area of Science:

  • Hematologic Malignancy
  • Orthopaedic Oncology
  • Skeletal Metastasis

Background:

  • Multiple myeloma commonly impacts the skeletal system, leading to pathologic fractures.
  • The incidence of multiple myeloma and associated fractures is rising.
  • Current treatments focus on chemotherapy and radiation to prolong survival.

Purpose of the Study:

  • To highlight the increasing incidence of multiple myeloma and associated pathologic fractures.
  • To emphasize the importance of a multidisciplinary approach in managing these fractures.
  • To discuss methods for stabilizing fractures and improving patient quality of life.

Main Methods:

  • Review of current chemotherapeutic agents and radiation therapy protocols.
  • Discussion of various surgical and non-surgical methods for fracture stabilization.
  • Emphasis on collaborative care between orthopaedic surgeons and oncology teams.

Main Results:

  • Novel treatments are extending patient lifespan.
  • Effective methods exist for fracture stabilization, function restoration, and pain reduction.
  • Individualized treatment plans are crucial for managing myeloma-related fractures.

Conclusions:

  • A collaborative approach between orthopaedic surgeons and oncologists is essential.
  • Management strategies should focus on improving quality of life and pain relief for patients.
  • Early diagnosis and intervention are key to managing skeletal complications in multiple myeloma.