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Updated: May 31, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
Prevention of type 1 diabetes
1School of Clinical Sciences, University of Bristol, and Second Floor, Learning and Research, Southmead Hospital, Bristol BS10 5NB, UK.
Introduction/Background:
Type 1 diabetes is a chronic autoimmune condition characterized by destruction of insulin-producing β cells within the pancreatic islets. It is associated with considerable morbidity and mortality. Incidence levels are rising worldwide.
Sources Of Data:
Pubmed search (Nov 2010) using keywords: Type 1 diabetes, prevention, trials, immunotherapy.
Areas Of Agreement:
The causes of disease are multifactorial with genetic and environmental factors playing a part. There is a long pre-clinical period before the onset of overt symptoms, which may be amenable to therapeutic intervention to prevent disease.
Areas Of Controversy:
The exact nature of causative environmental factors is unknown and much debated. Immunotherapeutic intervention may therefore represent the best option for disease prevention.
Growing Points:
Enhancement of 'regulatory' immune mechanisms currently shows the most promise as an approach to disease prevention.
Areas Timely For Developing Research:
Clinical trials of early immunotherapeutic intervention may be the answer to disease prevention.
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Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
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