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Updated: May 31, 2026
Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array
Published on: March 8, 2024
High-resolution extracellular stimulation of dispersed hippocampal culture with high-density CMOS multielectrode
1Bioelectronic Systems Lab, Department of Electrical Engineering, Columbia University, 500 West 120th Street 1300, New York, NY, USA. leina@ee.columbia.edu
Abstract:
We introduce a method to electrically stimulate individual neurons at single-cell resolution in arbitrary spatiotemporal patterns with precise control over stimulation thresholds. By exploiting a custom microelectronic chip, up to 65,000 non-Faradaic electrodes can be uniquely addressed with electrode density exceeding 6500 electrodes mm(-2). We demonstrate extracellular stimulation of dispersed primary hippocampal neuronal cultures using the chip at single-cell resolution.
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