Related Experiment Video
Updated: May 31, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Deregulated expression of superoxide dismutase-2 correlates with different stages of cervical neoplasia
Lara Termini1, Adhemar Longatto Filho, Paulo Cesar Maciag
1Ludwig Institute for Cancer Research - Hospital Alemão Oswaldo Cruz, São Paulo (SP), Brazil. ltermini@vrg.ludwig.org.br
Objective:
Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme may be involved in carcinogenesis, particularly in lung, gastric, colorectal and breast cancer.
Methods:
In the present study, we have evaluated SOD2 protein levels by immunohistochemistry (IHC) in 331 cervical histological samples including 31 low-grade cervical intraepithelial neoplasia (LSIL), 51 high-grade cervical intraepithelial neoplasia (HSIL), 197 squamous cervical carcinomas (SCC) and 52 cervical adenocarcinomas (ADENO).
Results:
We observed that SOD2 staining increases with cervical disease severity. Intense SOD2 staining was found in 13% of LSIL, 25.5% of HSIL and 40% of SCC. Moreover, 65.4% of ADENO exhibited intense SOD2 staining.
Conclusions:
Differences in the expression of SOD2 could potentially be used as a biomarker for the characterization of different stages of cervical disease.
