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Updated: May 31, 2026

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging
Published on: February 24, 2021
Functional ultrasound imaging of the brain
Emilie Macé1, Gabriel Montaldo, Ivan Cohen
1Institut Langevin, Ecole Supérieure de Physique et de Chimie Industrielles Paris Tech, Centre National de la Recherche Scientifique (CNRS) UMR7587, Institut National de la Santé et de la Recherche Médicale U979, Université Paris VII, Paris, France.
Abstract:
We present functional ultrasound (fUS), a method for imaging transient changes in blood volume in the whole brain at better spatiotemporal resolution than with other functional brain imaging modalities. fUS uses plane-wave illumination at high frame rate and can measure blood volumes in smaller vessels than previous ultrasound methods. fUS identifies regions of brain activation and was used to image whisker-evoked cortical and thalamic responses and the propagation of epileptiform seizures in the rat brain.
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