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Mesenchymoproliferative disorders (MPD) in simian AIDS associated with SRV-2 infection

C C Tsai1, C C Tsai, S T Roodman

  • 1Department of Pathology, St. Louis University School of Medicine, MO.

Journal of Medical Primatology
|January 1, 1990
PubMed

Insights

Simian retroviral infections can cause mesenchymal proliferative disorders (MPD) in macaques. These findings highlight the role of simian retrovirus type 2 (SRV-2) in the development of MPD.

Area of Science:

  • Veterinary Pathology
  • Primate Virology
  • Oncology

Background:

  • Macaques with Simian Acquired Immunodeficiency Syndrome (SAIDS) can develop mesenchymal proliferative disorders (MPD).
  • Simian retrovirus type 2 (SRV-2) infection is associated with these disorders.

Purpose of the Study:

  • To investigate the role of SRV-2 in the etiopathogenesis of MPD in macaques.
  • To characterize the mesenchymal cells involved in SRV-2-associated MPD.

Main Methods:

  • Observation of MPD in SRV-2 infected macaques.
  • Establishment of continuous cell lines from affected tissues.
  • Immunophenotyping of cultured cells.
  • Xenograft and allograft transplantation studies.

Main Results:

  • 165 macaques exhibited fibromatosis and fibrovascular proliferation mimicking Kaposi's sarcoma.
  • Arteriopathies and congenital pulmonary sequestration with MPD were noted in SRV-2 positive monkeys.
  • SRV-2 was identified in all tissues and established cell lines.
  • Transplantation of cultured cells induced MPD lesions in recipients.

Conclusions:

  • SRV-2 plays a significant role in the development of MPD in macaques.
  • The study identified heterogeneous mesenchymal cells as the source of MPD.
  • These findings provide insights into virus-associated tumorigenesis.

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